Colorful, handwoven squares hung on lines between palm trees in foreground & small blue, gold & white Nat Geo ship in background.
Aerial view of Cartagena, Colombia, with modern high-rise buildings and colorful Caribbean buildings including a church.
Female expedition leader shows off local insets at the the Smithsonian Tropical Research Institute, Barro Colorado, Panama.
Zodiac boat moves through small muddy river among palm trees & rainforest on a sunny day exploring the Panama rainforest.
View Photos
Central America Caribbean Cruise

Panama & Colombia: Exploring The Caribbean Coast

Spend 8 days discovering natural and cultural treasures of the Caribbean coast of Panama and Colombia aboard the 100-guest National Geographic Quest. Hike into dense rainforests that harbor extraordinary biodiversity, glide through little-explored inlets by Zodiac and kayak, and meet the indigenous inhabitants of a secluded Panamanian archipelago where age-old traditions remain part of everyday life.

Experience the diverse heritage of stunning cities and remote towns off the beaten path, from the Arab-influenced architecture of Colombia’s Santa Cruz de Lorica to the bustling shores of Santa Cruz del Islote—the most densely populated island in the world. Cruise from Panama to Colombia or cruise from Colombia to Panama.

Highlights of these cruises from Panama to Colombia (or reverse) include special permission to anchor at Gatun Lake, which forms a major part of the Panama Canal, and a special nighttime crossing of the complex lock system of the Panama Canal. Visit Portobelo, named by Christopher Columbus in 1502, and hike around lush jungles searching for howler monkeys, toucans and parrots. Meet the people who live in Guna Yala, who are the first native group to achieve political autonomy in Latin America.

Celebrate the birthplace of the sombrero vueltiao in the village of Tushin, observing hat makers at their best. Move from white-sand beaches to the densely populated Santa Cruz del Islote, the most densely populated island on Earth. Every moment of this 8-day small ship cruise, whether eastbound or westbound, is spent exploring the diverse culture, flora and fauna of Colombia, Panama and the Caribbean Coast.

Travel aboard the 100-passenger National Geographic Quest. This purpose-built small expedition ship is ideal for exploring Central America’s Caribbean coastline. Appreciate the onboard expedition technology, including a hydrophone, splash-cam, underwater video camera and video microscope.

Read on for details about these cruises to Colombia and Panama, or learn more about AdventureSmith’s Caribbean cruises and Caribbean trips.



Itinerary

Eastbound Panama & Colombia: Exploring the Caribbean Coast Itinerary

The eastbound Panama & Colombia: Exploring the Caribbean Coast cruise begins in Panama City, Panama, transits the Panama Canal, and ends in Cartagena, Colombia.

Route map of Panama & Colombia: Exploring the Caribbean Coast small ship cruise, operating between Panama City & Cartagena, with visits to Gatun Lake, Portobelo, Guna Yala, Capurgana, Sapzurro, Santa Cruz del Islote, San Antero, Tuchin, Santa Cruz de Lorica & Cispata Bay.
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Day 1
Embark Panama City, Panama

Upon arrival in Panama City this afternoon, take a short transfer to the port in Balboa. Embark the ship in the evening to begin the transit of the Panama Canal to the Caribbean Sea.

Accommodations

National Geographic Quest

Meals

dinner

Read More
Day 2
Gatun Lake, Barro Colorado & Panama Canal Crossing

By special permission, the ship anchors overnight in Gatún Lake, a vast artificial lake that forms a major part of the Panama Canal. In the morning, disembark on Barro Colorado, a hilltop transformed into an island by the damming of the Chagres River to build the Panama Canal. Visit the Smithsonian Tropical Research Institute and learn about initiatives to protect and study the extraordinary biodiversity of one of our planet’s most studied tropical forests and site of National Geographic studies.

Alternatively, engage in the wildness of the region by taking a hike into the jungle, a Zodiac across the vast lake or a boat ride to the mouth of the Chagres to explore the Panama Rainforest Discovery Center. The luminosity of the evening heightens the drama of your transit through the complex lock system of the legendary Panama Canal, 50 miles long and passage for some 14,000 ships yearly.

Accommodations

National Geographic Quest

Meals

breakfast, lunch, dinner

Read More
Day 3
Portobelo

This morning, arrive at Panama’s Caribbean coast and step ashore at the historic town of Portobelo. Named by Cristopher Columbus in 1502, Portobelo, or “beautiful port,” was one of the most important Spanish trading centers in the New World. Explore the town’s 17th- and 18th-century Spanish colonial fortifications, designated a UNESCO World Heritage site. Later, hike the surrounding jungle in search of native parrots and unruly howler monkeys.

Accommodations

National Geographic Quest

Meals

breakfast, lunch, dinner

Read More
Day 4
Guna Yala Archipelago

Wake up and find yourself amidst the Guna Yala archipelago (known also as the San Blas Islands), a scattering of 368 tiny, white-sand isles off the northeast coast of Panama. Spend the day exploring paradise where the Guna people still live as their ancestors did–in thatched huts making ancient handicrafts such as molas, colorful panels of stitched fabric. Deeply committed to their culture, the Guna are admired as a politically autonomous community where women make the rules and gender fluidity is celebrated.

In the afternoon, go offshore and explore the vibrant marine world of this breathtaking utopia by snorkel, kayak and stand-up paddleboard.

Accommodations

National Geographic Quest

Meals

breakfast, lunch, dinner

Read More
Day 5
Capurgana & Sapzurro, Colombia

Call at the wonderfully isolated villages of Sapzurro and Capurgana, positioned only 3 miles apart on the stunning coast of Caribbean Colombia. Set out on a nature walk on the Capurgana-Sapzurro trail. In this area, the ranges of two species of howler monkeys overlap as both the mantled and the Colombian red howler monkeys are here. Watch for toucans, parrots, trogons, occasionally scarlet macaws and possibly three-toed sloths while traversing the tropical forest trails between the villages. Or choose a shorter hike across an international, transcontinental frontier to Panama.

Walk through the border crossing, perched high on a bluff, before descending to the beach at the Panamanian village of La Miel. The sheltered waters of the bay at Sapzurro back in Colombia beckon for a pleasant kayak or paddleboard around this tropical inlet. Finish the day at sunset in the village of Capurgana.

Accommodations

National Geographic Quest

Meals

breakfast, lunch, dinner

Read More
Day 6
Santa Cruz de Lorica, San Antero & Tuchín

Visit Santa Cruz de Lorica on the banks of the Sinú River, a melting pot of cultures from throughout Europe and the Middle East. Stroll the central square and notice how the city’s distinct influences live harmoniously, spotlighted in the architecture of the stunning Spanish-colonial cathedral and historic buildings in colorful Arabic styles. A folkloric show will be performed on the riverfront malecón during your walking tour.

Enjoy lunch at a local restaurant before traveling to the nearby indigenous village of Tuchín. Watch craftsmen as they make hats that are considered Colombia’s national symbol, the sombrero vueltiao, and meet the local Zenú, celebrated for their ingenious irrigation systems.

Your ship will remain anchored in San Antero overnight. Pending conditions, you may visit Tuchín in the morning, and Santa Cruz de Lorica in the afternoon.

Accommodations

National Geographic Quest

Meals

breakfast, lunch, dinner

Read More
Day 7
Cispatá Bay & Sanguare Natural Reserve

The day begins by exploring Cispatá Bay, where you’ll spend the morning among the most extensive area of mangroves on Colombia’s Caribbean coast. Local community guides accompany us to share their insight and knowledge of the prolific wildlife. Join naturalists from local conservation group Asocaiman as they release rehabilitated young caimans back into the wild.

After lunch on board, we’ll venture over to the Sanguare Natural Reserve. This former cattle ranch, part of the national system of protected areas, offers great opportunities to explore on foot or by water. Learn of the conservation work being done and explore the tropical dry forests, coastal lagoons, and sea grass beds. Enjoy kayaking or paddleboarding, or dig your toes in the sand and sip a chilled refreshment.

Accommodations

National Geographic Quest

Meals

breakfast, lunch, dinner

Read More
Day 8
Disembark Cartagena, Colombia

Disembark in Cartagena and transfer to the airport for flights home.

Accommodations

n/a

Meals

breakfast

Read More
Details
Inclusions, Terms & Notes

Included

Accommodations aboard ship; meals as indicated; beer, wine & full bar; excursions; services of expedition leaders, naturalist staff, expert guides and a ship’s doctor; park fees; use of kayaks and snorkeling equipment; all port charges and service taxes; basic WiFi (enhanced and premium packages available for purchase). Gratuities for all departures of National Geographic Explorer, Orion, Endurance, Resolution, Sea Cloud, Jahan and Lord of the Glens.

Exclusions

Immigration fees; air transportation; extensions; meals not indicated; reserve wines & premium spirits; gratuities for all departures of Delfin II, Endeavour II, Islander II, Venture, Quest, Sea Bird and Sea Lion; personal items such as emails, laundry, voyage DVD, etc.; and insurance of any kind.

Payment & Cancellation

In order to confirm this trip, a deposit of 15% of the total trip cost is required per person at time of booking. The balance of the trip price is due 120 days before the departure date. Special payment terms apply for groups of 8 or more; inquire for details. Guests who must cancel their trip for any reason must do so in writing. Standard cancellations are subject to the following per-person fees, based on number of days prior to departure:
120 or more days – 100% of deposit**
119 to 90 days – 50% of total trip cost
89 to 0 days – 100% of total trip cost
**Advance payments will be credited in the form of a Lindblad Expeditions Travel Certificate, valid for 12 months from the date of cancellation, and which may only be applied towards final payment on any future booking. 

Terms & Conditions

This trip is subject to AdventureSmith Explorations Terms and Conditions. Please read this information carefully and call us if you have any questions. A Traveler Information Form, which includes a release of liability, must be completed and signed by all travelers. Your Adventure Specialist will send you a unique link to complete this form along with a packing list and extensive pre-departure and travel insurance information upon booking confirmation.

Arrival & Departure

The eastbound Panama & Colombia: Exploring the Caribbean Coast cruise begins in Panama City, Panama (PTY), and ends in Cartagena, Colombia (CTG). Plan flights to arrive to Panama by 2:00pm on Day 1 of the itinerary. On Day 8 of the itinerary, enjoy breakfast aboard before disembarking after 1:00p.m.  If you would like assistance with international flights, please visit our Booking Flights resource page.

Activities

Whether you are looking for light activity options or more challenging outdoor pursuits, the ship’s crew can tailor most excursions to suit your skill level. Adventure activities may include hiking, kayaking and stand-up paddleboarding, inflatable boat/skiff excursions, photography, morning yoga and stretching, land treks and wildlife observation.

Room Configuration

In addition to listed Solo cabin rates, select double-occupancy cabins may be available for single occupancy with a single supplement fee. If you would like to share accommodations with another guest of the same gender, we will be happy to try to accommodate you in select cabin categories. This program allows you to pay the per person double-occupancy rate whether or not a roommate is found. Contact AdventureSmith for further details and availability.

Families & Children

Travelers under the age of 18 at time of travel save $500, at double occupancy. There is no special kids programming on this itinerary.

Travel Insurance

Protect your travel investment with insurance. Our partners at Travelex Insurance offer a variety of plans and policies to fit every trip and budget. For best value and coverage for pre-existing medical conditions, consider purchasing a policy at time of booking. Learn more about travel insurance or get a free quote.

Itinerary Notes

Use the itinerary as a guide only. Itineraries may be altered due to weather, wildlife, national park regulation or at the captain’s discretion. The ability to be flexible makes this type of small ship cruising unique.

Westbound Panama & Colombia: Exploring the Caribbean Coast Itinerary

The westbound Panama & Colombia: Exploring the Caribbean Coast cruise begins in Cartagena, Colombia, transits the Panama Canal, and ends in Panama City, Panama.

Route map of Panama & Colombia: Exploring the Caribbean Coast small ship cruise, operating between Panama City & Cartagena, with visits to Gatun Lake, Portobelo, Guna Yala, Capurgana, Sapzurro, Santa Cruz del Islote, San Antero, Tuchin, Santa Cruz de Lorica & Cispata Bay.
Read More
Day 1
Embark Cartagena, Colombia

Arrive in Cartagena, one of the major port cities of Colombia, and transfer to the ship to begin your journey along the Caribbean Coast.

Accommodations

National Geographic Quest

Meals

dinner

Read More
Day 2
Sanguare Natural Reverse & Cispata Bay

The day begins by exploring Sanguare Natural Reserve. This former cattle ranch, now part of the national system of protected areas, offers great opportunities to explore on foot or by water. Learn of the conservation work being done and explore the tropical dry forests, coastal lagoons, and sea grass beds. Enjoy kayaking or paddleboarding, or dig your toes in the sand and sip a chilled refreshment.

After lunch on board, venture to Cispatá Bay, where we’ll spend the afternoon among the most extensive area of mangroves on Colombia’s Caribbean coast. Local community guides accompany us to share their insight and knowledge of the prolific wildlife. Join naturalists from local conservation group Asocaiman as they release rehabilitated young caimans back into the wild.

Accommodations

National Geographic Quest

Meals

breakfast, lunch, dinner

Read More
Day 3
San Antero, Santa Cruz de Lorica & Tuchín

Today, visit Santa Cruz de Lorica on the banks of the Sinú River, a melting pot of cultures from throughout Europe and the Middle East. Stroll the central square and notice how the city’s distinct influences live harmoniously, spotlighted in the architecture of the stunning Spanish-colonial cathedral and historic buildings in colorful Arabic styles. A folkloric show will be performed along the riverfront malecón during our walking tour.

Enjoy lunch at a local restaurant before traveling to the nearby indigenous village of Tuchín. Watch craftsmen as they make hats that are considered Colombia’s national symbol, the sombrero vueltiao, and meet the local Zenú, celebrated for their ingenious irrigation systems.

Pending conditions, you may visit Tuchín in the morning, and Santa Cruz de Lorica in the afternoon.

Accommodations

National Geographic Quest

Meals

breakfast, lunch, dinner

Read More
Day 4
Capurgana & Sapzurro

Call at the wonderfully isolated villages of Sapzurro and Capurgana, positioned only 3 miles apart on the stunning coast of Caribbean Colombia. Set out on a nature walk on the Capurgana-Sapzurro trail. In this area, the ranges of two species of howler monkeys overlap as both the mantled and the Colombian red howler monkeys are here. Watch for toucans, parrots, trogons, occasionally scarlet macaws and possibly three-toed sloths while traversing the tropical forest trails between the villages.

Or choose a shorter hike across an international, transcontinental frontier to Panama. Pass through the quick, walk-through border crossing perched high on a bluff before descending to the beach at the Panamanian village of La Miel. The sheltered waters of the bay at Sapzurro back in Colombia beckon for a pleasant kayak or paddleboard around this tropical inlet. Finish the day at sunset in the village of Capurgana.

Accommodations

National Geographic Quest

Meals

breakfast, lunch, dinner

Read More
Day 5
Guna Yala Archipelago, Panama

Wake up and find yourself amidst the Guna Yala archipelago (known also as the San Blas Islands), a scattering of 368 tiny, white-sand isles off the northeast coast of Panama. Spend the day exploring paradise where the Guna people still live as their ancestors did—in thatched huts making ancient handicrafts such as molas, colorful panels of stitched fabric. Deeply committed to their culture, the Guna are admired as a politically autonomous community where women make the rules and gender fluidity is celebrated.

In the afternoon, go offshore and explore the vibrant marine world of this breathtaking utopia by snorkel, kayak and stand-up paddleboard.

Accommodations

National Geographic Quest

Meals

breakfast, lunch, dinner

Read More
Day 6
Portobelo

In the morning, arrive at the historic town of Portobelo, or “beautiful port,” so named in 1502 by Cristopher Columbus and a critical Spanish trading center in the New World. The day here explores 17th- and 18th-century Spanish fortifications, designated a UNESCO site. Later, hike the surrounding jungle in search of native parrots and unruly howler monkeys.

Accommodations

National Geographic Quest

Meals

breakfast, lunch, dinner

Read More
Day 7
Gatún Lake, Barro Colorado & Panama Canal Crossing

By special permission, the ship anchors overnight in Gatún Lake, a vast artificial lake that forms a major part of the Panama Canal. In the morning, disembark on Barro Colorado, a hilltop transformed into an island by the damming of the Chagres River to build the Panama Canal. Visit the Smithsonian Tropical Research Institute and learn about initiatives to protect and study the extraordinary biodiversity of one of our planet’s most studied tropical forests and site of National Geographic studies.

Alternatively, engage in the wildness of the region by taking a hike into the jungle, a Zodiac across the vast lake, or a boat ride to the mouth of the Chagres to explore the Panama Rainforest Discovery Center. The luminosity of the evening heightens the drama of your transit through the complex lock system of the legendary Panama Canal, 50 miles long and passage for some 14,000 ships yearly.

Accommodations

National Geographic Quest

Meals

breakfast, lunch, dinner

Read More
Day 8
Disembark Panama City, Panama

Disembark in Panama City and transfer to the airport for your flight home.

Accommodations

n/a

Meals

breakfast

Read More
Details
Inclusions, Terms & Notes

Included

Accommodations aboard ship; meals as indicated; beer, wine & full bar; excursions; services of expedition leaders, naturalist staff, expert guides and a ship’s doctor; park fees; use of kayaks and snorkeling equipment; all port charges and service taxes; basic WiFi (enhanced and premium packages available for purchase). Gratuities for all departures of National Geographic Explorer, Orion, Endurance, Resolution, Sea Cloud, Jahan and Lord of the Glens.

Exclusions

Immigration fees; air transportation; extensions; meals not indicated; reserve wines & premium spirits; gratuities for all departures of Delfin II, Endeavour II, Islander II, Venture, Quest, Sea Bird and Sea Lion; personal items such as emails, laundry, voyage DVD, etc.; and insurance of any kind.

Payment & Cancellation

In order to confirm this trip, a deposit of 15% of the total trip cost is required per person at time of booking. The balance of the trip price is due 120 days before the departure date. Special payment terms apply for groups of 8 or more; inquire for details. Guests who must cancel their trip for any reason must do so in writing. Standard cancellations are subject to the following per-person fees, based on number of days prior to departure:
120 or more days – 100% of deposit**
119 to 90 days – 50% of total trip cost
89 to 0 days – 100% of total trip cost
**Advance payments will be credited in the form of a Lindblad Expeditions Travel Certificate, valid for 12 months from the date of cancellation, and which may only be applied towards final payment on any future booking. 

Terms & Conditions

This trip is subject to AdventureSmith Explorations Terms and Conditions. Please read this information carefully and call us if you have any questions. A Traveler Information Form, which includes a release of liability, must be completed and signed by all travelers. Your Adventure Specialist will send you a unique link to complete this form along with a packing list and extensive pre-departure and travel insurance information upon booking confirmation.

Arrival & Departure

The westbound Panama & Colombia: Exploring the Caribbean Coast cruise begins in Cartagena, Colombia (CTG), and ends in Panama City, Panama (PTY). Plan flights to arrive to Cartagena by 2:30pm on Day 1 of the itinerary. On Day 8 of the itinerary, enjoy breakfast abaord before disembarking after 1:00p.m. If you would like assistance with international flights, please visit our Booking Flights resource page.

Activities

Whether you are looking for light activity options or more challenging outdoor pursuits, the ship’s crew can tailor most excursions to suit your skill level. Adventure activities may include hiking, kayaking and stand-up paddleboarding, inflatable boat/skiff excursions, photography, morning yoga and stretching, land treks and wildlife observation.

Room Configuration

In addition to listed Solo cabin rates, select double-occupancy cabins may be available for single occupancy with a single supplement fee. If you would like to share accommodations with another guest of the same gender, we will be happy to try to accommodate you in select cabin categories. This program allows you to pay the per person double-occupancy rate whether or not a roommate is found. Contact AdventureSmith for further details and availability.

Families & Children

Travelers under the age of 18 at time of travel save $500, at double occupancy. There is no special kids programming on this itinerary.

Travel Insurance

Protect your travel investment with insurance. Our partners at Travelex Insurance offer a variety of plans and policies to fit every trip and budget. For best value and coverage for pre-existing medical conditions, consider purchasing a policy at time of booking. Learn more about travel insurance or get a free quote.

Itinerary Notes

Use the itinerary as a guide only. Itineraries may be altered due to weather, wildlife, national park regulation or at the captain’s discretion. The ability to be flexible makes this type of small ship cruising unique.

Rates & Dates

Cruise Rates & Dates

Rates are variable per remaining availability and are subject to change.

Oct 19 - Oct 26, 2025
National Geographic Quest • 8 days
From $6810USD
Per Person
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Oct 26 - Nov 02, 2025
National Geographic Quest • 8 days
From $6810USD
Per Person
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Nov 02 - Nov 09, 2025
National Geographic Quest • 8 days
From $6810USD
Per Person
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Nov 09 - Nov 16, 2025
National Geographic Quest • 8 days
From $6810USD
Per Person
Read More
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Oct 31 - Nov 07, 2026
National Geographic Quest • 8 days
From $6450USD
Per Person
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Nov 07 - Nov 14, 2026
National Geographic Quest • 8 days
From $6450USD
Per Person
Read More
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Nov 12 - Nov 19, 2027
National Geographic Quest • 8 days
From $6450USD
Per Person
Read More
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Nov 19 - Nov 26, 2027
National Geographic Quest • 8 days
From $6450USD
Per Person
Read More
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Accommodation

Learn about the Small Ship on Your Itinerary

Expedition Ship
National Geographic Quest

Purpose built to cruise coastal waters, shallow coves and fast-moving channels, the 100-guest National Geographic Quest is a state-of-the-art expedition vessel designed for supreme comfort and enhanced wildlife viewing.

Deal

Current Deals on This Trip

Add to Wishlist
Offer expires December 31st, 2025
Groups Save 5% On Select 2025 Nat Geo Cruises Worldwide

Save 5% when traveling as a group of 8 or more on a variety of 2025 National Geographic expeditions worldwide.

Expert Review

Ship Reviews from our Experts so You Know What to Expect

Mary Montalbano • August 1st, 2023
Expert Aboard: Venture & National Geographic Quest Reviews

Learn from two AdventureSmith experts about identical sister ships Nat Geo Venture and Quest. Tips on choosing your cabin, what the food is like and why choose to sail aboard.

Our experts will save you hours.

A single conversation with us is worth hours of internet scrolling. Find your next best trip with ease, then book with the confidence of our 20+ year experience.

Extend Your Trip

Additional Travel Options Before or After Your Cruise

In conjunction with this cruise, the following pre- and post-cruise options are available for a seamless land-and-sea group travel experience with National Geographic guides and fellow passengers. Contact AdventureSmith Explorations for pricing.

Panama City & San Lorenzo is a 3-day pre/post-cruise exploration of Panama City. Take a private tour at the Panama Canal Museum at the Miraflores Locks, as well as a former U.S. Army base, Frank Gehry’s BioMuseo, and two UNESCO World Heritage Sites—the historic Casco Viejo Old Town and the natural beauty and wildlife of the San Lorenzo Protected Area.

Add to Wishlist
6 - 6 Day Cruise
Exploring Costa Rica: Guanacaste, Santa Rosa & Rincon de la Vieja

Navigate the pristine coastline of Costa Rica’s national parks and preserves on this 6-day voyage aboard the 100-guest National Geographic Quest. Discover tropical forests on foot, horseback, and soaring by zipline throughout wildlife-rich parks and preserves.

Special Offer
From $4536USD
Jan Mar Nov Dec
Add to Wishlist
5 - 8 Day Cruise
Kontiki Pura Vida Expedition Cruises

Come aboard the 18-guest Kontiki Wayra boutique yacht to experience Costa Rica's kaleidoscope of biodiversity in an exclusive way that most travelers miss. An attentive crew, two naturalist guides and a menagerie of activity gear provides the base for both rejuvenation and daily active and cultural excursions.

From $4200USD
Jan Feb Mar Apr May Jun Jul Aug Nov Dec
Add to Wishlist
8 - 8 Day Cruise
Costa Rica & The Panama Canal

Explore Costa Rica and Panama aboard the 100-guest National Geographic Quest. Transit the legendary Panama Canal and visit Barro Colorado with Smithsonian scientists and expert National Geographic guides. Hike, kayak, swim and snorkel.

Special Offer
From $6320USD
Jan Feb Mar Nov Dec
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